Clsi M22a3 Pdf Jun 2026

However, the decision by CLSI to withdraw the standard reflects a smart consolidation of information. Having separate documents for "Control Materials" (M22) and "Performance Standards" (M100) created a risk of discrepancy between the two. By moving the QC guidelines into M100, CLSI ensures that the acceptable limits for QC strains are updated annually in tandem with the breakpoint changes.

For all non-exempt media, inoculate the plates using specific American Type Culture Collection (ATCC) control strains as designated by the standard. Test for using positive control organisms.

: You can still find the full 44-page PDF version for purchase on the CLSI Shop or authorized retailers like the ANSI Webstore . clsi m22a3 pdf

Draft a based on these standards.

The PDF is priced at , depending on the vendor and any optional features (such as a multi‑user license or a redline version that highlights changes from the previous edition). However, the decision by CLSI to withdraw the

Given that M22-A3 no longer applies to CLIA-regulated US laboratories, what should laboratories use instead?

Provides specific incubation conditions for media quality control. For all non-exempt media, inoculate the plates using

Understanding CLSI M22-A3: The Standard for Quality Control of Microbiological Culture Media

Under CLIA regulations, laboratories must perform quality control on all culture media. However, CLIA allows laboratories to follow CLSI M22-A3 guidelines to reduce the frequency of testing for commercially prepared exempt media. If a laboratory chooses not to follow M22-A3, it must perform full QC testing on every lot of every medium type used, creating a massive operational and financial burden. Summary of Benefits