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Antisense oligonucleotides (ASOs) targeting the GRET-39 transcript have been administered subcutaneously in non-human primates. A 60% reduction in circulating GRET-39 was achieved, correlating with reduced fasting insulin and HbA1c. The main concern is off-target liver inflammation, which is currently being addressed by modifying the ASO chemistry. GRET-39
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While we await pharmaceutical interventions, what can individuals do to manage their own levels? Emerging evidence suggests three levers: The main concern is off-target liver inflammation, which